Ali Al Saeed
King Faisal University, Saudi Arabia
Title: Ethanolic extract of red cabbage (Brassica oleracea) ameliorates hyperglycemia and hyperlipidemia in Streptozotocin-diabeic rats
Biography
Biography: Ali Al Saeed
Abstract
Diabetes mellitus has become the most common metabolic disease worldwide. The edible leaves of Red cabbage (Brassica oleracea) are taken raw in salad or in the cooked form. Therefore, it was of interest to evaluate the hypoglycemic and hypolipidemic effects of ethanolic (50%) extract of the leaves of red cabbage to blood glucose, glycated hemoglobin (HbA1c) and lipid profile in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in male Wistar rats by injecting rats with a single dose (60 mg/kg body weight) of streptozotocin. Diabetic rats showed significant elevation in serum glucose, glycated hemoglobin (HbA1c) total cholesterol (TC), and triacylglycerol (TG). Daily oral supplementation (250 mg/kg body weight) of leaves of red cabbage extract for 40 days to STZ-induced diabetic rats significantly ameliorated serum glucose (p < 001), HbA1c (p < 001), TC (p < 01), and TG (p < 01). By comparison, a standard anti-hyperglycemic drug, glibenclamide when administered at a dose of 10 mg/kg body weight, reduced blood glucose, HbA1c, TC and TGs levels. It is concluded that ethanolic extract of red cabbage reduced the blood level of glucose, HbA1c and lipids and it was more effective than glibenclamide in reducing blood glucose.